Medical Industry Advisor Profile

Daniel R. Yazbeck, M.S.
Executive Advisor
daniel.yazbeck@telesiaadvisors.com

Mr. Yazbeck, who comes from a science based strategic business development and marketing background, brings a wealth of marketing, joint venture and business management experience to Telesia from his tenure in both a top 50 fortune 500 company and an $80 billion/year multinational conglomerate. He also has an extensive scientific and techical background, with several patents and publications in the field of biopharmaceutical drug and technology development as well as in the application of electronic technology to the medical and life sciences industry.

Market Expertise

Drug Discovery and Development Market
• Cell Biology Market (Biochemical and Cellular Assays)
• High Throughput Screening Market
• Genomics Market (Sequencing | Microarrays | Diagnostics)
• Proteomics Market
• Laboratory Supplies Market

Medical Diagnostics Market
• Point of Care Diagnostics Market
• Molecular Diagnostics Market

Technical Expertise

Pharmeceutical and Medical Industry
• Good Manufacturing Procedures (GMP)
• Standard Operating Procedures (SOP's)
• FDA regulations
• CFR Part 11 Compliance
• Organic Synthesis
• Biocatalysis and Biotransformations
• Microbiology
• DNA / RNA Synthesis
• Sequencing
• Protein Microarray and DNA Microarray Screening
• Electrophysiology
• Molecular Assays Development
• Chromatography
• Spectrophotometry
• Electrophoresis
• Radiolabelling
• Molecular Biology (Cloning, Gene Expression)
• Analytical Instrumentation (LC-MS, NMR, GC, CE, HPLC, robotic handlers, UV-platereaders)

Semiconductor and Consumer Electronics Industry
• MEMS/Precision Etching Technology
• Ferroelectric Thin Film Deposition Technology
• Acousto-Optic Technology
• Ultrasonic Separation Technology
• Wireless Technology
• Substrate and Mounting Technology

Publications
(Main Contributor is First Author)

1. Daniel Yazbeck; Martinez, C.A. ; Hu, S.; Tao, J. Challenges in the Development of an Efficient Enzymatic Process in the Pharmaceutical Industry. Tetrahedron Asymmetry, 2004, 15, 2757-2763.
2. Daniel Yazbeck; Tao, J.; Martinez, C. A.; Kline, B. J.; Hu, S. Automated Enzyme Screening Methods for the Preparation of Enantiopure Pharmaceutical Intermediates. Adv. Synth. Catal . 2003 , 345 , 524-532.
3. Daniel Yazbeck ; Durao, P. J.; Xie, Z.; Tao, J. A High Throughput Metal Ion Based Methods for Nitrilase Screening, J. Mol. Cat. B , 2006, 39, 156-159 (special issue).
4. Daniel Yazbeck ; Derrick, A.; Panesar, M.; Deese, A.; Gujral, A.; Tao, J. Enzymatic Hydrolysis of Racemic and Cis/Trans Ethyl Bicyclo[3.2.0]hept-6-ylidene-acetate: Solvent Effect and NMR Study, Org. Process. Res. Dev. , 2006 , 10 (3), 655 -660.
5. Rossi, F., Daniel Yazbeck, et. al. Process Research and Development and Scale-up of a 4,4-Difluoro-3,3-dimethylproline Derivative. Org. Process. Res. Dev., 2008, 12, 322–338
6. Xie, J.; Feng, J.; Garcia, E.; Bernett, M.; Daniel Yazbeck ; Tao, J. Cloning and Optimization of a Nitrilase for the Synthesis of (3S)-3-Cyano-5-methyl Hexanoic Acid, J. Mol. Cat. B, 2006.
7. Hu, S.; Martinez , C.; Kline,B.; Daniel Yazbeck ; Tao, J. Efficient and Scalable Enzymatic Process for the Production of (2S)-4,4-Difluoro-3,3-dimethyl-N-Boc-proline, a Key Intermediate in the Synthesis of HIV Protease Inhibitors, Org. Process. Res. Dev., 2006, ASAP 2006:239222 (special issue).
8. Lijian Chen, Young Mi Kim, David J. Kucera, Katheryn E. Harrison, Sogole Bahmanyar, Jill M. Scott, and Daniel Yazbeck. Fluorination-Free Synthesis of a 4,4-Difluoro-3,3-Dimethylproline Derivative. J. Org. Chem. 2006, 5 (3) .
9. Hu, S., Tat, D., Martinez , C., Daniel Yazbeck , Tao, J. An Efficient and Practical Chemoenzymatic Preparation of Optically Active Secondary Amines. Organic Letters, 2005 , 7 , 4329-4331.
10. Martinez , C.A. , Daniel Yazbeck , Tao, J. An Efficient Enzymatic Preparation of Rhinovirus Protease Inhibitor Intermediates. Tetrahedron. 2003 , 60 , 759-764.
11. Daniel Yazbeck , Damha M.J. Molecular Requirements for degradation of a modified sense RNA strand by Escherichia coli Ribonuclease H1. Nucleic Acid Research. 2002, 30, 3015-2025.
12. Daniel Yazbeck. Molecular Requirements for Degradation of RNA in DNA/RNA Hybrids by RNase H. MSc. Thesis, McGill University, Montreal, Canada, 2001.
13. Daniel Yazbeck; Derrick, A.M. Resolution of racemic cis/trans ( 1R,5R)-Ethyl bicyclo[3.2.0]hept-6-ylideneacetate using Candida Antartica Lipase B. Industrial Biotransformations, Wiley-VCH, 2nd edition, 2005.

Patents
(Authorship in Alphabetical Order)